Amination of nitrogen heterocycles

Many natural products, drugs, or plant protection agents are amino-nitrogen heterocycles. Thus, methods for their efficient synthesis are of considerable practical and technical interest. This chapter will discuss primarily the advances made in the amination of nitrogen heterocycles since the comprehensive review by Shepherd and Fedrick on Reactivity of Azine, Benzoazine, and Azinoazine Derivatives with Simple Nucleophiles was published in this series in 1%5 (65AHC145). 

For many years, chloride, and to a lesser degree bromide, ions have been the most important leaving groups for preparative and large scale aminations of nitrogen heterocycles. 

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