Ibuprofen Amikacin

However, it is important to note that the addition of nephrotoxic agents, such as amphotericin B, aminoglysides (e.g., gentamicin, tobramidn, or amikacin), and non-steroidal anti-inflammatory drugs (NSAIDs e.g., naproxen, ibuprofen, or ketorolac) may potentiate the nephrotoxic effects of the calcineurin inhibitors. 

Noninterfering acetaminophen, allopurinol, amikacin, amoxapine, amytal, bretylium, caffeine, carbamazepine, carisoprodol, chloramphenicol, chlordiazepoxide, chlorpropamide, clonazepam, codeine, diazepeun, disop30 amide, droperidol, ethinamate, ethinamate, etho-suximide, fluphenazine, flurazepam, furosemide, gentamicin, haloperidol, hydrochlorothiazide, hydro yzine, ibuprofen, kanamycin, lidocaine, loxapine, meperidine, mepho-barbital, meprobamate, methaqualone, methotrexate, morphine, nafcUlin, naloxone, neomycin, perphenazine, phenacetin, phenobarbital, phenytoin, prazepam, primidone, procaine, propoxyphene, reserpine, salicylamide, salicylic acid, secobarbital, spironolactone, theophyUine, thiopental, thioridazine, tobramycin, valproic acid, verapeunil... 

In another study, preterm infants were given amikacin 20 mg/kg every 36 hours (gestational age less than 30 weeks) or every 24 hours (gestational age 30 to 31 weeks) with either ibuprofen lysine 10 mg/kg within 6 hours of birth, then a further 5 mg/kg dose 24 and 48 hours later, or placebo. The half-life of amikacin was increased from 12.4 to 16.4 hours and its clearance was reduced by 40% in infants who also received intravenous ibuprofen lysine. Reductions in amikacin clearance, independent of gestational age were found by the same authors in another study in which preterm infants with gestational ages of between 24 and 34 weeks were given amikacin and ibuprofen. ... 

In contrast, another study in preterm infants given amikacin found no changes in its pharmacokinetics when ibuprofen or indometacin were given. ... 

Simultaneous acetanilide, N-acelylcysteine, N-acetylprocainamide, ampicillin, aspirin, butabarbital, butalbital, chlorpropamide, cimetidine, codeine, cyheptamide, diazoxide, di-flunisal, diphylbne, disopyramide, ethchlorvynol, gentisic acid, glutethimide, heptabar-bital, hexobarbital, ibuprofen, indomethacin, ketoprofen, mefenamic acid, mephen doin, methaqualone, methsuximide, methyl sahcylate, methyprylon, morphine, naproxen, nir-vanol, oxphenylbutazone, phenacetin, phensuximide, phenylbutazone, procainamide, sal-icylamide, salicylic acid, sulfamethoxazole, sulindac, tolmetin, trimethoprim, vancomycin Noninterfering amikacin, gentamicin, meprobamate, netilmicin, quinidine, tetracycline, tobramycin, valproic acid... 

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