Amidoalkyl naphthol derivatives

IL = (CH3CH2)3NCH2(CH2)2CH2S03H HSO4 Fig. 12.67 Synthesis of amidoalkyl naphthol derivatives in the presence of [TEBSA][HSOJ... 

However, Hmited work has appeared with the carbon nucleophiles. Recently, an efficient tandem process has been developed that would allow the reaction of o-QM intermediates with carbon/nitrogen nucleophiles in situ to provide xanthene, naphtho(pyrano)pyridine/amidoalkyl naphthol derivatives under solvent-free and simple reaction conditions (Scheme 7.63). Xanthenes and benzoxanthenes are... 

The reaction of 2-naphthol with aromatic aldehydes in the presence of acid catalyst is known to provide ortho-quinone methides (o-QMs). The o-QMs were reacted with amides or urea to produce l-amidoalkyl-2-naphthol derivatives (Fig. 12.68). 

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