Naming amides

Nitriles are classified as carboxylic acid derivafives because fhey are convened fo car boxylic acids on hydrolysis The condifions required are similar fo fhose for fhe hydrol ysis of amides namely healing m aqueous acid or base for several hours Like fhe hydrolysis of amides nilrile hydrolysis is irreversible m fhe presence of acids or bases Acid hydrolysis yields ammonium ion and a carboxylic acid... 

Amides. Names for amides are derived from the names of the acid radicals (or from the names of acids by replacing acid by amide) for example, S02(NH2)2, sulfonyl diamide (or sulfuric diamide) NH2SO3H, sulfamidic acid (or amidosulfuric acid). 

Nitriles are classified as carboxylic acid derivatives because they are converted to carboxylic acids on hydrolysis. The conditions required are similar- to those for the hydrolysis of amides, namely, heating in aqueous acid or base for several hours. Like the hydrolysis of amides, nitrile hydrolysis is ineversible in the presence of acids or bases. Acid hydrolysis yields fflnmonium ion and a carboxylic acid. 

If there is one alkyl group attached to the nitrogen atom, the compound is a secondary amide. Name the alkyl group, and give it location letter N- to indicate that it is bonded to the nitrogen atom. 

An amide name is based on the name of the carboxylic acid of the same number of carbon atoms, but the -oic ending is changed to amide. Amides with alkyl groups on the nitrogen are substituted amides and are named the same as N-substituted amides, except the parent name is preceded by the name of the alkyl substituent and a capital N precedes the substituent name. 

We have extensively studied the solution conformation of the metal-free ferrichromes, deferriferrichrome, deferriferricrocin and deferriferri-chrysin (29, 40). By plotting the PMR chemical shift versus temperature for the different amides, an estimate of the relative extent of steric shielding or intramolecular H-bonding can be obtained from their linear slopes. Fig. 2, a and b, show this kind of plot for deferriferrichrome both in H20 and in (CDa SO. It is evident from such graphs that while little distinction can be made between the extent of shielding of the amides in water, at least two amides, namely those denoted by G3 (a glycyl... 

Substituents on the nitrogen are placed as prefixes and are indicated by N- followed by the name of the substituent. There are no spaces between the prefix and the amide name. For example ... 

The names of the alkyl groups form the first part of each amide name. 

Among all carboxylic acid derivatives, the amides, RCNR2, are the least susceptible to nucleophilic attack. After a brief introduction to amide naming, this section describes then-reactions. 

The mrbamide foimvla, CO(NH2)a (Dumas, 1830). According to this early formula, urea is the diamide of carbonic acid and can be prepared by the general reaction for the preparation of amides, namely, the dehydration of the corresponding ammonium salt. 

Each amide name contains a parent name that tells you the number of carbons in the parent chain. Note that this parent chain must contain the carbonyl group. The parent name is derived by replacing oic acid in the corresponding carboxylic acid name with amide. ... 

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