Amides Acetohydroxamic acid

Amidation of alkyl aryl ethers.2 Either anisole or phenetole undergoes para-amidation exclusively on reaction with acetohydroxamic acid in polyphosphoric acid (yields 50-60%). Thus phenetole is converted into the drug phenacetin in -50% yield (equation I). [Pg.2]

Matrix metalloproteinases are a recently discovered class of zinc enzymes able to degrade extracellular matrix components. [Zn(OH)TpCum,Me)] has been reported to cleave activated amides and ester.130 The reaction of [Zn(OH)(TpPB,Me)] with acetohydroxamic acid has been also described,131 as well as protonolis of zinc thiolate bond in [Zn(SPh)(Tpph)].132... [Pg.460]

Big Chemical Encyclopedia