Amide-linked carbohydrate oligomers

Amide-linked carbohydrate-based oligomers with defined secondary structures were first engineered by Szabo et al. [66]. )8-Methoxy neuraminic acid was used as the monomer unit, and solid phase techniques were employed in the construction of oligomers ranging from dimer to octamer. Caproamide was incorporated at the car-boxy terminus to prevent solvation of the terminal residue, a phenomenon commonly referred to as fraying (Fig. 37). The hydrophobic end group provided directionality... 

Carbopeptoid, a word derived from the noun peptide that means an oligomer in which carbohydrate units are linked through amide bonds [J. H. Jones, Editorial,/. Peptide Sci. 2006, 12, 79]. 

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