Amidation of Glutamate Is an Elaborately Regulated Process

Amidation of Glutamate to Glutamine Is an Elaborately Regulated Process 

Even more important in the regulation of E. coli glutamine synthase activity is the reversible ATP-dependent adenylylation of a specific tyrosyl residue on each subunit. As the enzyme becomes progressively more adenylylated (up to the fully adenylylated form which contains 12 AMP groups per enzyme molecule), the enzyme becomes progressively less active. 

The adenylylation reaction and the deadenylylation reaction are regulated by the nitrogen supply in the cell. The immediate small-molecule effectors of this regulatory system are glutamine and a-ketoglutarate. A high-glutamine- 

Amino acids and other luce ogen-.. ton -ootirdR 

Nitrogen fixation by some bacteria and algae, e.g., Klebsiella, Azotobacter, Nitrifying Rhizobium 

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