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Ambit Biosciences

Ambit Biosciences, http //www.ambitbio.com. Accessed date 07. 05. 2010. [Pg.203]

Fig. 8.5 High-throughput screening at 10mMforWBZ 4 (red) andimatinib (STI 571, blue, control) over a battery of human kinases displayed in a T7-bacteriophage library (Ambit Biosciences, San Diego, CA). Hit values are reported as percentage-bound kinase. Reprinted from the [14], copyright 2007 with permission from the American Society for Clinical Investigation... Fig. 8.5 High-throughput screening at 10mMforWBZ 4 (red) andimatinib (STI 571, blue, control) over a battery of human kinases displayed in a T7-bacteriophage library (Ambit Biosciences, San Diego, CA). Hit values are reported as percentage-bound kinase. Reprinted from the [14], copyright 2007 with permission from the American Society for Clinical Investigation...
As shown in Chap. 8, WBZ 4 is a re-engineered version of imatinib with an enhanced specificity needed to curb imatinib s potential cardiotoxicity. The inhibitory impact of WBZ 4 is restricted to KIT, PDGFR, and JNK, all with nanomolar affinity, as corroborated by screening against a T7-bacteriophage library of kinase displays (Ambit Biosciences, CA) [13],... [Pg.201]

See other pages where Ambit Biosciences is mentioned: [Pg.165]    [Pg.22]    [Pg.81]    [Pg.108]    [Pg.165]    [Pg.22]    [Pg.81]    [Pg.108]   
See also in sourсe #XX -- [ Pg.81 , Pg.108 ]



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