Amathia wilsoni, amathaspiramides

Amathaspiramide E (128) from the New Zealand bryozoan Amathia wilsoni exhibits strong activity in the antiviral assay against Polio virus [102],... 

Tyrosine-derived metabolites in this section do not include spiro-cyclohexadienyl-isoxazolines and related compounds (Sect. 3.22.3.3) or bastadins (Sect. 3.22.3.4), but they do include tyrosine-derived alkaloids that were covered in the Alkaloids section in the first survey (1). The prolific bryozoan Amathia convoluta, collected in Tasmania, has yielded amathamide G (1953) (1814), the latest of several amath-amide alkaloids from the genus Amathia (1). A Florida collection of this animal furnished the new convolutamines A-E (1954—1958) (1815), F (1959), and G (1960) (1425), and a Tasmanian sample of this bryozoan afforded convolutamine H (1961) (1319). A study of Amathia convoluta from the North Carolina coast has yielded volutamides A-E (1962-1966) (1816). Volutamides B and C reduce feeding by the pinfish (Lagodon rhomboids) and the urchin (Arbacia punctulata), respectively, and volutamides B and D are toxic toward larvae of the hydroid Eudendrium carneum. The New Zealand Amathia wilsoni contains the six novel amathaspiramides A-F (1967-1972) (1817). 

Morris BD, Prinsep MR (1999) Amathaspiramides A-F, Novel Brominated Alkaloids from the Marine Bryozoan Amathia wilsoni. J Nat Prod 62 688... 

Morris, B. D., Prinsep, M. R. Amathaspiramides A-F, novel brominated alkaloids from the marine bryozoan Amathia wilsoni. J. Nat. Prod. 1999, 62, 688-693. 

In early 2012, Arash came across the amathaspiramides (la-f), a family of marine alkaloids that were isolated in 1999 by Prinsep and coworkers from a New Zealand collection of the bryozoan Amathia wilsoni (Figure 1). The structures were determined by detailed NMR analysis, including NOESY... 

Amathaspiramides A-F form an original group of alkaloids isolated from a New Zealand form of Amathia wilsoni. The cytotoxic activities of these amides are moderate, but amathaspiramide E has a strong activity against the poliomyelitis virus (Morris and Prinsep, 1999). 

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