Amantadine observational studies

Observational studies In a retrospective observational study of 11 patients receiving amantadine for the treatment of Parkinson s Disease three patients reported side effects. Lower extremity oedema was reported in an 86-year-old man receiving amantadine (100 mg twice daily) after 5 months of treatment. This resolved when amantadine was discontinued. Hallucinations were reported in a 71-year-old man in the first 2 months of treatment with amantadine. A reduction in amantadine dosage from 100 mg twice daily to 100 mg once daily did not result in improvement and the drug was therefore discontinued, which resulted in resolution of symptoms. 

A recent study of a construct containing the transmembrane helix and the amphi-pathic helix of the S3 IN mutant [167], which was reversely isotope labeled for four hydrophobic residues, facilitated sequential resonance assignments for 23 residues. All secondary chemical shifts were found to be characteristic for a-helical secondary structure. Peak doubling of most resonances as well as cross peaks between resonance pairs in PDSD spectra indicates that the tetramer is a dimer of asymmetric dimers instead of a symmetric homotetramer. Upon addition of amantadine, no significant shift changes were observed, which is in agreement with the drugs resistance of this mutant. 

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