Amoxicillin Aluminium hydroxide

Aluminium/magnesiium hydroxide and aluminium hydroxide do not significantly affect the bioavailability of amoxicillin or amoxicillin with clavulanic acid (co-amoxiclav). Antacids may reduce the absorption of the hydrochloride salt of pivampicillin. 

The pharmacokinetics of amoxicillin 1 g, and both amoxicillin and clavulanic acid (given as co-amoxiclav 625 mg), were not significantly altered by 10 doses of aluminium/magnesium hydroxide (Maalox) 10 mL, with the last dose given 30 minutes before amoxicillin. Another study found that four 40-mg doses of aluminium hydroxide (Aludrox) given at 20 minute intervals had no effect on the pharmacokinetics of either amoxicillin or clavulanic acid (given as co-amoxiclav 750 mg with the second dose of antacid). ... 

Deppermam K-M, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P. Influence of ranitidine, pirenzepine, and aluminium m nesium hydroxide on die bioavailability of various antibacterials, includii amoxicillin, cep exin, dojq cycline, and amoxicillin-clavulanic acid. Antimi-crob Agents Chemother 9Z9)3> i, 1901-7. 

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