Alternate Uses of HLCs in Toxicity Assessment

Although dynamic perfusion cnlture has not been widely applied in studies of iPSC differentiation, it has shown 

It is clear that iPSC HLCs currently lack many of the key qualities required to be a one-for-all model of hepatotoxicity however, that does not preclnde the use of iPSC HLCs in modeling other less metabolicaUy dependent endpoints. 

APPLICATION OF PLURIPOTENT STEM CELLS IN DRUG-INDUCED LIVER INJURY SAEETY ASSESSMENT 

In short, it is important to find what purpose iPSC HLCs are currently fit for. 

The capturing of the patient genotype is a fundamental advantage of iPSC HLCs over more traditional and hESC-derived models of hepatotoxicity. DILI is often idiosyncratic in nature and can occur in only very small numbers of patients, in the case of abacavir and flucloxacillin, which are 

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