Alpha-toco

S)(l S,2 R) configuration. It has a molecular formula of C 25 H 35 N 3 6 S. The capsules are available for oral administration in strengths of 50 and 150 mg. Each 50-mg capsule contains the inactive ingredients D-alpha toco-pheryl polyethylene glycol 1000 succinate (TPGS), poly-... 

Kamm, J.J., et al. Inhibition of Amine-Nitrate Hepatotoxicity by Alpha-Toco pherol/ Toxical. Appl. Pharmacol.. 41, 575 (1977). 

Note that alpha tocopherol has three chiral centers, giving rise to eight isomeric forms. The naturally occurring form is known as d-alpha tocopherol or (2R,4 R,8 R)-alpha-toco-pherol. The synthetic form, d/-alpha tocopherol or simply alpha tocopherol, occurs as a racemic mixture containing equimolar quantities of all the isomers. 

Munteanu, A., Zingg, J.M., Ogru, E, Libinaki, R., Gianello, R., West, S., Negis, Y., and Azzi, A., Modulation of cell proliferation and gene expression by alpha-toco-pheryl phosphates relevance to atherosclerosis and inflammation, Biochem. Biophys. Res. Commun. 318 (1), 311-316, 2004. 

Leonard, S.W., Terasawa, Y., Farese, R.V., Jr., and Traber, M.G., Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-toco-pherol transfer protein — null mice. Am. J. Clin. Nutr. 75 (3), 555-560, 2002. 

Free radical scavenging activities of different phenolic acids, caffeic acid (CA), ferulic acid (FA) and p-coumaric acid (p CA) and natural antioxidants alpha tocopherol (alpha-toco) and BHA a synthetic antioxidant were compared with sinapic acid (SA). As indicated in Figure 15.10 under the tested conditions, the radical scavenging activity of the phenolic acids in the DPPH system decreased in the following order ... 

Oral E, Greenbaum ES, Malhi AS. Harris WH, Muratoglu OK. Characterization of irradiated blends of alpha-toco[4ierol and UHMWPE. Biomaterials 2005 November 26(33) 6657-63. 

Christen, S., Jiang, Q., Shigenaga, M. K., and Ames, B. N. (2002). Analysis of plasma toco-pherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric... 

Alpha-d-tocopherol can also he readily synthesized in the laboratory. In the course of the synthesizing process, however, alpha-d-tocopherol is produced together with alpha-l-toco-pherol, its mirror-image molecule. The latter is not found in nature, and it has less biological activity than the so-called d-isomer. To get aroimd this confusing business, we rate vitamin E supplements in terms of international units (lu) of activity. In other words, the composition of the synthetic and the natural versions may not be identical, but a two himdred lu tablet will have the same level of activity, regardless of its origin. 

Berzen J. Luketic D. Stabilised polyethylene moulding materials, esp. for implants containing polyethylene with molecular wt. 10 5-10 7. antioxidant, and toco[4ierol, esp. alpha- tocopherol or vitamin E. as stabiliser. European Patent 613,923 1994. 

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