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Alpha-spending functions

The methods as presented here assume that the analyses are equally spaced in terms of the numbers of patients involved at each stage. It is possible to deviate from this in a planned way using so-called alpha-spending functions. [Pg.153]

Figure 19.3 Alpha-spending functions for Pocock and O Brien-Fleming approaches. Figure 19.3 Alpha-spending functions for Pocock and O Brien-Fleming approaches.
Demets DL, Lan KKG (1994) Interim Analysis - the alpha-spending function approach. Statistics in Medicine 13 1341-1352. [Pg.313]

See other pages where Alpha-spending functions is mentioned: [Pg.184]    [Pg.185]    [Pg.185]    [Pg.298]    [Pg.127]    [Pg.128]    [Pg.128]    [Pg.259]    [Pg.260]    [Pg.262]    [Pg.184]    [Pg.185]    [Pg.185]    [Pg.298]    [Pg.127]    [Pg.128]    [Pg.128]    [Pg.259]    [Pg.260]    [Pg.262]    [Pg.262]    [Pg.263]   
See also in sourсe #XX -- [ Pg.153 , Pg.214 ]



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