17- alpha hydroxylase deficiency

G-13) (G-13) 17-alpha hydroxylase deficiency. I here is a decrease in both glucocorticoid and androgen production. The mineralocorticoid path is open and this may cause hypertension through excess mineralocorticoids. 

Jansen, G.A., Mihalik, SJ., Watkins, P.A., Moser, H.W., Jakobs, C, Denis, S. Wanders, R.J.A. (19%) Biochem. Biophys. Res. Commun. 229, 205-210. Phytanoyl-CoA hydroxylase is present in human liver, located in peroxisomes, and deficient in Zellweger syndrome direct, unequivocal evidence for the new, revised pathway of phytanic acid alpha-oxidation in humans. 

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