Allylic Substitution Reactions via n-Allyl Complexes

Since the soft carbon nucleophiles attack the Ti-allyl group from the side opposite to palladium, the asymmetric induction at the carbon nucleophiles is difficult with 

2 Asymmetric Catalysis with Chiral Ferrocenylphosphine Ligands 

Intramolecular asymmetric allylic substitution reactions have been applied to the synthesis of optically active cyclic compounds. The high efficiency of the dihydroxylated ferrocenylphosphine 8b has been shown in the cyclization of 2-butenylene dicarbamates 52 to form optically active 4-vinyl-2-oxazolidones 53, which are 

The ferrocenylphosphine (R)-(S)-8a is also effective for the asymmetric allylation of several other active methine compounds, including 2-acetyl-l-tetralone, 6,6-dimethyl-2-acetylcyclohexanone, 2-acetylcyclooctanone, 1 -phenyl-2-methylbutane- 

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