Cyclic allylic monoesters

The synthetic utility of the above transformations stems from the fact that many monoesters obtained as a result of hydrolysis may be converted to pharmaceutically important intermediates. For example, the optically active glycerol derivative (27) is a key intermediate in the production of p-blockers. Allyl derivative (25) may be converted into (3)-paraconic acid [4694-66-0] ((JT)-5-oxo-3-tetrahydrofurancarboxylic acid) that is a starting material for the synthesis of (3R)-A-factor. The unsaturated chiral cyclic monoacetate (31) is an optically active synthon for prostaglandins, and the monoester (29) is used for the synthesis of platelet activating factor (PAF) antagonists. 

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