Allyl p-chlorophenyl ether

Typical procedure A mixture of p-chlorophenol (128 mg, 1 mmol), NaOH (40 mg, 1 mmol) and THF (10 mL) was stirred for 10 min allyldiisobutylteUuronium bromide (360 mg, 1 mmol) was then added. The reaction mixture was stirred for another 5 h at room temperature under nitrogen. Aqueous saturated NaHCOj solution was added and extracted with CH2CI2. The extract was dried over anhydrous MgS04 and concentrated in vacuo. The residue was chromatographed on sihca gel with 95 5 hexane-ethyl acetate as eluent to give a colourless oil of allyl p-chlorophenyl ether (145 mg, 86%). 

Jia, Zhou, and coworkers reported flow Claisen rearrangement without solvent [61]. The reaction of allyl p-chlorophenyl ether at 220 °C proceeded well with 24 min residence time to give 82% yield of product in a microflow system, while the same reaction in a batch reactor gave 14% yield of the product (Scheme 5.44). 

---

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

---