Allosteric effect sequential model

Two theoretical models for allosteric effects have been proposed to explain the mechanism for ligand-protein cooperative interactions the concerted (or symmetry) model of Monod, Wyman, and Changeux and the sequentially induced-fit model of Koshland. The nomenclature associated with allosterism and cooperativity originated from the concerted model. Both models assume that... 

Sequential Models Also Can Account for Allosteric Effects... 

Both the MWC and the sequential models are phenomenological and do not answer at an atomic level of detail the fundamental question of how the binding of a ligand or its modification results in allosteric effects. 

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