Mouse allophenic

Mintz, B. (1970). Gene expression in allophenic mice. In Control Mechanisms in the Expression of Cellular Phenotypes (Padykula, H., ed.), pp. 15—42. Academic Press, New York. 

Fig. 73. Obtaining allophenic mice with striped coloration. (After McLaren, 1973)...

Significant variability in the proportions of C3H and C57BL/6 cells in allophenic mice was observed during the investigation of the clonal growth model of the differentiation of the spinal column and skull parts. The cells of C57BL/6 mice predominated in the skull bones while C3H cells comprised most of the spine -especially the lumbar-sacral regions (Moore and Mintz, 1972). 

Fig. 74. Clonal origins of the photoreceptor cell layer of the mouse retina. The drawing is a two-dimensional reconstruction from serial sections of the retina of an allophenic mouse with approximately equal numbers of normal (+/+) and retinal degeneration strain (rdird) cells. The development, followed by death, of the rdjrd cells leaves null areas (shown in black) on which clonal mapping is based. A stellate pattern (arrows point to five -f / + components) suggests that the visual cells of each eye are derived from only ten clonal initiator cells that proliferate radially from a small circle. (After Mintz, 1971)...

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