Allometric scaling, estimation pharmacokinetic parameters

The use of half-life incorporates the variables that can influence the rate of drug elimination, those that affect distribution and clearance, whereas the use of systemic clearance focuses on the process of elimination, and corrections can be made for the extent of binding to plasma proteins and for estimated maximum life-span potential. Corrections seem to be justifiable when the human is included in the interspecies scaling technique. The necessity to apply correction factors, however, detracts from the use of allometric scaling for predicting the values of pharmacokinetic parameters. 

---