Allogenic grafts

Bonini, C. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science, 21 , 1719-1724. 

The major alloantigens (i.e. antigens responsible for rejection of allogeneic grafts) are the MHC proteins. Although there are two distinct classes of MHC protein (described in section 4.1) the MHC molecules actually comprise a number of subclasses... 

Reduced intensity or nonmyeloablative transplants have been developed in order to reduce early posttranslant morbidity and mortality while maximizing the CVT effect of the allogeneic graft. The advantage to this approach is that many patients who would otherwise not be eligible for allogeneic HSCT can now be offered a potentially curative therapy. 

Of note, human-derived dural replacement products became popular in the 1960s, employing freeze-dried cadaveric dural grafts. However, these allogeneic grafts presented additional risks as serious infections were reported, including prion (eg, Creutzfeld-Jakob) disease and lentivirus transmission (Centers for Disease Control and Prevention, 2008 Walcott et al., 2014), and thus were discontinued from use. 

Conversion of alkaloids in an allogenic graft of different genotypes of lupine... 

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