Allogeneic transplant, defined

Between 1949 and 1954, Jacobson, Lorenz, Barnes and Loutit made important experiments in mice showing that cells from the spleen or the bone marrow protected from death caused by radiation. Of note, a different evolution was observed after syngeneic and allogeneic transplantation, since mice in the latter group usually died due to complications defined as secondary disease . This experience anticipated the most relevant problem after this type of transplantation, graft-versus-host disease (GVHD). 

Fig.6.2.1a,b.A 48-year-old man with Pseudomonas aeruginosa pneumonia after allogeneic hematopoietic stem cell transplantation, a Close-up view of an anteroposterior chest radiograph shows an ill-defined opacity in the right upper lobe, b Corresponding HRCT scan at the same level shows multiple branching linear opacities and some areas of lobular consolidation... 

Fig. 6.2.7. Cytomegalovirus (CMV) infection in a 23-year-old man with acute myeloid leukemia and allogeneic HSC transplantation. CT scan obtained at the level of the inferior pulmonary veins shows diffuse ground-glass attenuation and multiple small ill-defined nodules in both lungs...

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