Allergy topical application studies

Eczematous skin lesions are characterized by their chronic evolution and their frequent spread, despite the topical administration of corticosteroids. They are caused, as was shown by Hjorth and Trolle-Lassen (1963), by parabens contained in corticosteroid ointments. Patch tests done with different types of parabens yielded positive responses. Local application of pure corticosteroids, without preservatives, brought about rapid healing. This type of allergy, falsely related to corticosteroids, was particularly studied by Shorr (1968) 1 % of his patients treated for chronic dermatitis suffered from this allergy. 

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