Allergic disease inhibition mechanisms

Arooj M, Thangapandian S, John S, Hwang S, Park JK, Lee KW (2012) Computational studies of novel chymase inhibitors against cardiovaseular and allergic diseases mechanism and inhibition. Chem Biol Drug Des 80(6) 862-875. doi 10.1111/cbdd.12006... 

Much of the available information on immunotoxic evaluation of anticholinesterases involves pesticides. However, exposure to low levels of pesticides does not appear to adversely affect the immune system. The effects observed arc not always dose related and only rarely occur at exposures not producing systemic toxicity. Allergic responses and various degrees of autoimmune diseases have been reported in workers occupationally exposed to pesticides however, this effect may be mediated by alteration of proteins rather than inhibition of cholinesterases. Modulation of immune responses, particularly the interference with host defense mechanisms, has been experimentally induced fora variety of anticholinesterase pesticides. 

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