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Indirect sympathomimetics (B) are agents that elevate the concentration of NE at neuroeffector junctions, because they either inhibit re-uptake (cocaine), facilitate release, or slow breakdown by MAO, or exert all three of these effects amphetamine, metham-phetamine). The effectiveness of such indirect sympathomimetics diminishes or disappears (tachyphylaxis) when ve-Ltillmann, Color Atlas of Pharmacology 2000 Thieme All rights reserved. Usage subject to terms and conditions of license. [Pg.88]

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