Alkynyl epoxides kinetic resolution

Hie same autliors also studied tlie alkylation of alkynyl epoxides for fornialion of optically active a-aUenic alcohols under kinetic resolution ctmdilions fSdieme 8.29) [54]. 

When the allylic alcohol needed for asymmetric epoxidation is unavailable from a commercial source, reasonably general synthetic routes have been developed to allylic alcohols of several different substitution patterns. Good methods are available for the preparation of 3-substituted allylic alcohols, whereas synthesis of 2-substituted allylic alcohols is more problematic. The substrates for kinetic resolution, 1-substituted allylic alcohols, frequently can be derived by addition of alkenyl or alkynyl organometallic reagents to aldehydes followed by modification of the resulting product as required. 

The same authors also studied the alkylation of alkynyl epoxides for formation of optically active ct-allenic alcohols under kinetic resolution conditions (Scheme 8.29) [S4],... 

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