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Alkynes, cyclization with 2-iodobenzoic acids

New synthetic methods for benzodiazepine synthesis involving Ugi-type multicomponent/post-Ugi cyclization reactions continue to be of interest. Ugi reactions of indole-2-carboxaldehydes, isocyanides, amines, and 2-iodobenzoic acid derivatives led to intermediates which, with copper(I) catalysis, underwent intramolecular indole N-arylation to produce indolo-fused benzodiazepinones, such as 134 (13CC2894). 2-Azido-benzaldehyde, isocyanides, propargylamines, and nitrophenols underwent Ugi-type reaction, Smiles-type rearrangement, and intramolecular azide-alkyne cyclization to afford triazolo-fused benzodiazepinones such as 135... [Pg.541]

See other pages where Alkynes, cyclization with 2-iodobenzoic acids is mentioned: [Pg.226]    [Pg.105]    [Pg.423]    [Pg.424]    [Pg.105]    [Pg.117]    [Pg.105]    [Pg.247]    [Pg.12]   
See also in sourсe #XX -- [ Pg.225 , Pg.226 , Pg.227 ]



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0-Iodobenzoic acid

2- Iodobenzoic

2- Iodobenzoic acid 2- iodobenzoate

Alkynals, cyclization

Alkynes acidity

Alkynes cyclizations

Cyclization alkynes

Cyclization with Alkynes

Iodobenzoate

With alkynes

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