Alkylmagnesium chlorides

The position of the equilibrium depends upon the solvent and the identity of the specific organic group, but in ether lies well to the left for simple aryl-, alkyl-, and alkenylmagnesium halides.21 Solutions of organomagnesium compounds in diethyl ether contain aggregated species.22 Dimers predominate in ether solutions of alkylmagnesium chlorides. 

Preparative Methods phosphorus trichloride is allowed to react sequentially with alkylmagnesium chloride, methylmagnesium bromide, and BH3-THF complex in THF to give... 

Grignard Addition to Enones. The sultam generated from camphorsulfonic acid can also be used as a chiral auxiliary in the conjugate addition of Grignard reagents to enones. Simple alkylmagnesium chlorides add in a 1,4-fashion to afford imides (eq 19). ... 

Table 2. (EBTHI)Zr-catalyzed enantioselective carbomagnesation of unsaturated heterocycles with longer chain alkylmagnesium chlorides ... 

Table 4.7. (EBTHI) Zr-Calaly/cd Enantioscleetive Carbomagnesalion of Unsaluratcd Hctcrocyclcs with Longer Chain Alkylmagnesium Chlorides."... 

The reaction is carried out in ethereal solution it gives the best yields when alkylmagnesium chlorides are used the corresponding alkyl chlorides are by-products. The process has its main interest for preparation of primary amines whose amino group is attached to a secondary or tertiary carbon atom. Examples of its use and a tested. method of preparing chloramine are given in a review by Theilacker.1217 Also the unstable chloramine may be replaced by methoxylamine, which is easier to handle.1218... 

Reaction of alkylmagnesium chlorides with zinc methoxide in ether provides a highly valuable method to prepare salt-free dialkylzinc reagents, such as 34 or 35 (in ether solution [58] or solvent free [59]), that are otherwise difficult to obtain (Scheme 4.8). The approach takes advantage of the low solubility of magnesium methoxide in ether, which allows for its removal by filtration. 

Solutions of organomagnesium compounds in diethyl ether contain aggregated species. Dimers predominate in ether solutions of alkylmagnesium chlorides. The... 

Oppolzer W, Kingma AJ. Asymmetric induction on copper (I) chloride catalyzed 1,4-addition of alkylmagnesium chlorides to a,p-disubstituted ( )-enoylsultams and subsequent protonation. JSe/v. Chim. Acta 1989 72 1337-1345. 

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