Alkylating agents biological consequences

Modification of biological molecules (by reactions of addition or substitution), for instance, by alkylating agents or as a consequence of a coagulation of proteins... 

What are the biological consequences of the covalent modifications caused by alkylating agents One that we have already noted is the introduction of mutations opposite a modified base. Another one is the inhibition of DNA synthesis e.g., some of the acrolein adducts of guanine (Figure 13.8b) inhibit the incorporation of any base opposite to them, thus interfering with DNA s3uithesis and repair. Of note, many of these chemical adducts are removed by DNA repair enzymes only inefficiently or not at all the enzymes are apparently not accustomed to these peculiar types of modifications . 

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