Alkyl-substituted alkynyl substrates

After this seminal work, the alkynylation reaction with alkynyliodonium salts was applied to several classes of substrates, including diketones [36-38], ketoesters [36], malonates [36, 39], and aminomalonates [40, 41], The latter class of compounds is especially interesting, as it was also successful in the case of alkyl substituted alkynes. This was probably made possible by an efficient 1,2-shift of the nitrogen heteroatom. 

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