Alkyl halides alkyllithium reagents from

Atkyllithium reagents. This aromatic radical anion (1) is particularly effective for conversion of alkyl halides into alkyllithium reagents. These products are formed in 93-95% yield from reactions conducted in THF at — 78°. 

Reduction of carbon-halogen bond by metal yields carbanion. Reaction of alkyl halide with Mg in the presence of anhydrous ether as solvent generates Grignard reagent. The Grignard reagent behaves like a carbanion. Alkyllithiums are also obtained from alkyl halides and behave as carbanions. 

An alkyllithium, RLi, is prepared from an alkyl halide, RX, in much the same way as a Grignard reagent. To it is added cuprous halide, CuX, and then, finally, the second alkyl halide, R X. Ultimately, the alkane is synthesized from the two alkyl halides, RX and R X. 

Metal alkyls can be prepared in a simple manner from the main group halides (X = Cl, Br, I) and the appropriate alkyl Grignard reagent (RMgl) or the alkyllithium salt (RLi), as shown for the cadmium alkyls (Equation (2)).13 The elimination of impurities from the precursor source is of great importance, as any remaining impurities are invariably carried over into the growing semiconductor layers. Incorporation of impurities, even at levels as low as 1015 free carriers per cubic centimeter (one part in ca. 107), can drastically affect the electronic properties of the... 

Tertiary alkyllithiums are prepared in hydrocarbons from the appropriate alkyl chlorides with Li dispersions. Once the reaction is initiated, secondary reactions between the reagent and its precursor halide may cause low yields. Slow rates of addition of the alkyl chloride minimize these secondary reactions . Polycyclic and bridgehead reagents are less susceptable to such bimolecular reactions with their precursor chlorides. 

Vinyl halides react with alkyllithiums with the aid of a palladium(O) complex to give olefins stereospecifically in good yields. When Grignard reagents are employed instead of alkyllithium compounds, these reactions can be carried out catalytically with the palladium complex (Yamamura et al., 1975). or/Ao-Alkylated thiobenzophenones can be similarly prepared from 5-donor ligand or/Ao-metalated complexes (H. Alper and J. Kamenof, unpublished results). 

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