Alkenes other nitrating agents

The reaction of alkenes with nitrogen oxides and other nitrating agents have been extensively discussed by Olah, Topchiev, and in numerous reviews." ... 

Other alkenes in the substrate, and especially other alkynes, will react with the Ru catalyst. Samuel Danishefsky, of Columbia University and Sloan-Kettering Institute, recently completed Organic Lett. 2004, 6, 413) the total synthesis of the antimalarial and antitumor agent aigialomycin D. For the Ru-mediated macrocyclization of 4 to 5, the alkyne in the molecule was protected as the dicobalt octacarbonyl adduct. After the cyclization, the alkyne was deprotected by brief exposure to ceric ammonium nitrate. 

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