Alkaloids reuptake inhibitors

Harmala alkaloids are potent inhibitors of monoamine oxidase (Callaway and Grob 1998). Thus, if combined with other antidepressants, such as selective serotonin reuptake inhibitors, there is potential for serious side effects. Harmaline or its metabolites also cross the placental barrier (Okonmah et al. 1988). 

Cocaine (4.73), the local anesthetic tropane alkaloid of coca leaves, is a potent NE reuptake inhibitor but has no antidepressant activity. 

Serotonin - [ALKALOIDS] (Vol 1) - [GASTROINTESTINALAGENTS] (Vol 12) -biotransformation pathway [PFIARMACODYNAMICS] (Vol 18) -reuptake inhibitors [STIMULANTS] (Vol 22)... 

A Figure 7.2 Basic drugs and classes, the largest subgroup in the acid-base classification scheme. The alkaloids are (or at least once were) derived from plant matter, while nonalkaloids are generally synthetic or semisynthetic. Tropane alkaloids Include cocaine, while tryptamines include mescaline and psilocyn. Caffeine and theophylline are xanthine alkaloids. The selective serotonin reuptake inhibitors (SSRIs) include the second-generation SSRI antidepressants. Prozac (fluoxetine, shown) and Paxil belong to this class. 

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