Alkaloids related to 22-pyrrolidyl-5a-pregnane

Tomatillidine has been re-formulated as (58) as a result of certain new observations (i) a reference compound with a 2-pi peridein-3-one unit underwent a ring contraction during silica gel chromatography to a 2-acyl-2-pyrrolideine  

As a consequence of an X-ray diffraction analysis solamaladine is re-formulated as (60) rather than as an isomeric pi perideinone structure as suggested earlier, (Usubillaga et al, Acta Cryst., 1982, 38B, 966). 

---