Alkaloids protoberberines

The nomenclature and numbering of formulas for berberine and its derivatives is based on the system adopted by Buck, Perkin and Stevens for the parent substance of the series, protoberberine (XXIV). Awe has suggested that tetrahydroproioberberine should be called berbine and used as the basis of a system of names for these alkaloids. [Pg.336]

Interaction of Protoberberine Alkaloids with Nucleic Acid Structures. . . 176... [Pg.155]

Protoberberine Alkaloid-Triplex Nucleic Acid Interaction. 194... [Pg.156]

Protoberberine Alkaloid-Nucleic Acid Quadruplex Interaction. 196... [Pg.156]

Abstract Protoberberine alkaloids and related compounds represent an important class of molecules and have attracted recent attention for their various pharmacological activities. This chapter deals with the physicochemical properties of several isoquinoline alkaloids (berberine, palmatine and coralyne) and many of their derivatives under various environmental conditions. The interaction of these compounds with polymorphic DNA structures (B-form, Z-form, H -form, protonated form, triple helical form and quadruplex form) and polymorphic RNA structures (A-form, protonated form, triple helical form and quadruplex form) reported by several research groups, employing various analytical techniques such as spectrophotometry, spectrofluorimetry, circular dichro-ism, NMR spectroscopy, viscometry as well as molecular modelling and thermodynamic analysis to elucidate their mode and mechanism of action for structure-activity relationships, are also presented. [Pg.156]

Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties 157... [Pg.157]

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