Alkaloids from strychnos

Figure 86. Some alkaloids from Strychnos species.

Fr6d6rich, M., Tits, M., Golffin, E., Philippe, G., Grellier, P., Mol, P. D., Hayette, M.-P. and Angenot, L. 2004. In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambaren-sis. Planta Medica, 70 520-525. 

Verpoorte, R., Kodde, E. W., Van Doorne, H. and Baerheim Svendsen, A. 1978. Antimicrobial effect of the alkaloids from Strychnos afzelii. Planta Medica, 33 237-242. 

Activity of some alkaloids on Gram-positive and Gram-negative bacteria. Some alkaloids from Strychnos species. 

Indole alkaloids from Strychnos species and their anti-plasmodial and cytotoxic activities 03KPS425. 

In the early 1960s Battersby and Yeowell (196) isolated two quaternary alkaloids from Strychnos toxifera. These they called macusine A and macusine C, which they claimed to be epimeric compounds and for which they presented structures 66 and 67, respectively (Fig. 2). A little later Orazi et... 

The mixture of constituents [e.g., normacusine B (2), affinisine (8), Na-methylpericyclivine (41), voachalotine (64)] present in Peschiera van heur-ckii from the tropical rain forest in Bolivia is known for its alleged leishmani-cidal and bactericidal activity (37). Like many quaternary alkaloids, the major quaternary alkaloid from Strychnos angolensis, 11-methoxymacusine A (76), shows muscle-relaxant activity (187). The crude mixture of nine alkaloids present in Ervatamia yunnanensis is used in Chinese folk medicine for the treatment of hypertension (176). One of these alkaloids is a sarpagine derivative [voachalotine (64)]. 

Melinonine A. 16,17- Didehydro-16-( methoxycar-bonyl)-4,16a -dimethyloxayohimbanium. [C,jHj7N203] + Calabash-curare alkaloid from Strychnos meltnoniana Bail-lon, Loganiaceae. Isoln and structure Sc blit tier, Hohl. 

The complete stereostructure of divarine (27), a new bisindole alkaloid from Strychnos divaricans has been determined, by use of 2D NMR techniques [88]. 

Verpoorte R, Frederick M, Delaude C, Angenot L, Dive GM, Thepenier P, et al. Moandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Lx)gania-... 

Frederich M, Tits M, Angenot L. Indole alkaloids from Strychnos species and their antiplasmodial and cytotoxic activities. Chem Nat Comp 2003 39(6) 513-9. 

Saraswati S, Agrawal SS. Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo. Cancer Lett 2013 332(l) 83-93. 

Bisset NG, Bosly J, Das BC, Spiteller G (1975) Alkaloids from Strychnos henningsii. Revised structures for holstiine and rindline, proposed structure for holstiline. Phytochemistry 14 1411-1414... 

Mukherjee R, da Silva BA, Das BC, Keifer PA, Shoolery IN (1991) Structure and stereochemistry of divaricine, a new bisindole alkaloid from Strychnos divaricans Ducke. Heterocycles 32 985-990... 

Guianine and macrophylline A and B are designations given, previously, to alkaloids from Strychnos species (95). 

Nicoletti M, Goulart M F, DeLima R, Goulart A E, Delle Monache F, Marini-Bettolo G B 1984 Flavanoids and alkaloids from Strychnos pseudoquina. J Nat Prod 47 953-957... 

Galeffi, C, Nicoletti, M., Messana, I., and Marini-Bettolo, G.B. (1979) On the alkaloids of strychnos—XXXI 15-Hydroxystrychnine, a new alkaloid from Strychnos nux vomica L. Tetrahedron, 35,2545-2549. 

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