Alkaloids biosynthesis in Catharanthus

Figure 7.9 Intercellular and subcellular trafficking in alkaloid biosynthesis. A. Tropane alkaloid biosynthesis in Hyoscyamus muticus. B. Terpenoid indole alkaloid biosynthesis in Catharanthus roseus. C. Trafficking of the berberine bridge enzyme in Papaver somniferum cell cultures.

IRMLER, S., SCHRODER, G., ST-PIERRE, B CROUCH, N.P., HOTZE, M., SCHMIDT, J., STRACK, D MATERN, U., SCHRODER, J Indole alkaloid biosynthesis in Catharanthus roseus new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J., 2000,24, 797-804. 

GEERLINGS, A., MARTINEZ-LOZANO IBANEZ, M., MEMELINK, J., VAN DER HEIJDEN, R., VERPOORT, R., Molecular cloning and analysis of strictosidine P-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J. Biol. Chem., 2000,275,3051-3056. 

DE LUCA, V., FERNANDEZ, J.A., CAMPBELL, D., KURZ, W.G.W., Developmental regulation of enzymes of indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol, 1988, 86,447-450. 

MEIJER, A.H., VERPOORTE, R., HOGE, J.H.C., Regulation of enzymes and genes involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J. Plant Res., 1993, Special Issue 3, 145-164. 

Figure 2.12 A hypothetical view of compartmentation of indole alkaloid biosynthesis in Catharanthus roseus. Enzymes located with dashed arrows are hypothetical and circles indicate membrane associated enzymes (after Meijer et at, 1 993b). Cl OH, geraniol-1 0-hydroxylase NMT, 5-adenosyl-L-methionine 11 -methoxy 2,16-dihydro-16-hydroxytabersonine N-methyltransferase DAT, acetylcoenzyme A deacetylvindoline 1 7-0-acetyltransferase OHT, 2-oxyglutarate-dependent dioxygenase SSpC, strictosidine-((3)-glucosidase SSS, strictosidine synthase.

Rischer, H., Oresic, M., Seppanen-Laakso, T., Katajamaa, M., Lammertyn, R, Ardiles-Diaz, W., von Montagu, M.C.E., Inze, D., Oksman-Caldentey, K.-M. and Goosens, A. (2006) Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc. Natl. Acad. Sci. USA, 103,5614—9. 

Vazquez-Flota, F. and De Luca, V. (1998) Jasmonate modulates development and light-dependent alkaloid biosynthesis in Catharanthus roseus. Phytochemistry, 49,395-402. 

Gantet P. Transcription factor Agamous-Uke 12 from Arabidopsis promotes tissue-Uke organization and alkaloid biosynthesis in Catharanthus roseus suspension cells. Met. Eng. 2007 9 125-132. 155. 

Enzymes Characterized in Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus ... 

O. J. M. Goddijn, Regulation of terpenoid indole alkaloid biosynthesis in Catharanthus roseus." Ph.D. Thesis, Leiden University, 1992. 

Chapter 3, by Verpoorte, van der Heijden, and Moreno, summarizes the tremendous progress achieved in the past twenty years in the use of cell culture systems to delineate and express the pathway of monterpene indole alkaloid biosynthesis in Catharanthus roseus. The authors review the formation of the precursor units and then examine the enzymatic aspects of secondary metabolism. They conclude with an overview of the influence of exogenous materials on the regulation of alkaloid biosynthesis. 

Shukla AK, Shasany AK, Verma RK, Gupta MM, Mathur AK, Khanuja PSP (2010) Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Protoplasma 24 35-47. doi 10.1007/s00709-010-0120-1... 

Kulshrestha, M., Patra, B. et al. (2011) The transcription factor CrWRKYl positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol, 157, 2081-2093. 

---