Alkaloids akuammiline family

The akuammiline alkaloids, a family of nitrogen-based natural products comprised of complex scaffolds, found in many plants of the Apocyna-... 

Alkaloids that are proposed to derive biosyntheticaUy via cyclization of geis-soschizine (2), forming a bond between C—7 and C—comprise the akuammiline family (Figure 1). 

While the akuammiline family of alkaloids has been known and studied for over a century, only in the last few years successful total syntheses of... 

Recent Reports on the Isolation and Biological Activity of Members of the Akuammiline Alkaloid Family... 

There are now numerous scaffolds that comprise the akuammiline alkaloid family. Illustrated below are representative examples of the various architectures that can arise from the akuammiline and echitamine cores (Figure 2). 

RECENT REPORTS ON THE ISOLATION AND BIOLOGICAL ACTIVITY OF MEMBERS OF THE AKUAMMILINE ALKALOID FAMILY... 

Members of the akuammiline alkaloid family also hold promise for treatment of pain and inflammation. Scholarisin I (60) and scholarisin VI (65) were claimed as selective inhibitors of COX-2, while pseudoakuammigine (13) has been reported to have in vivo anti-inflammatory and analgesic activity in rats observed via the carrageenan-induced paw edema and tail flick models respectively. " Picrinine (5) has also been su ested to have antiinflammatory and analgesic activity in mice based on results from various in vivo assays, while (Z)-alstoscholarine (29) was disclosed to be an inhibitor of nuclear factor-KB. ... 

In addition to being involved with much of the early degradation and structural assignment work in the 1960s as well as writing the initial reviews for this family of alkaloids,Joule also reported synthetic efforts studying possible routes to the akuammiline famUy." " ... 

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