Akuammiline

Kopsia macrophylla provided two more new monoterpene alkaloids, kopsilactone (51) and kopsone (52), in addition to the known compounds 5,22-dioxokopsane, dregamine, akuammiline, tabemaemontanine, deacetylakuammiline, norpleiomutine and kopsolTine [56]. 

Three new compounds were obtained from the bark which were the Moxidcs of l6-ep<-deacetylakuammiline, akuammiline and 11,12-methylenedioxykopsinaline. Among the known alkaloids, the P-carboline alkaloid harmane, the quasidimer buchtienine and 167f-l9,20- -isositsirikine, were found for the first time in Kopsia. Harmane and buchtienine constitute the major alkaloids in die leaves [58]. 

Minfiensine (99) [43] exemplifies a variety of indole alkaloids containing the novel l,2,3,4-tetrahydro-9a,4a-(iminoethano)-9/7-carbazole ring skeleton. These include minfiensine (99), vincorine (100) [44], corymine (101) [45], and echitamine (102) [46] (Fig. 4). They exhibit a number of impressive biological activities, including significant anticancer activity [47]. Since the first characterization of the first akuammiline alkaloid member echitamine (102), more than 80 years ago, only a few successful syntheses of this challenging tetracyclic system have been reported. 

Recent Reports on the Isolation and Biological Activity of Members of the Akuammiline Alkaloid Family... 

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