Aliphatic hydrocarbons mutagens

Mersch-Sundermann V, Muller G, Hofmeister A. 1989. Examination of mutagenicity of organic microcontaminations of the environment. IV. Communication the mutagenicity of halogenated aliphatic hydrocarbons with SOS-Chromotest. Zentralbl Hyg Umweltmed 266-271. 

Roldan-Aijona T, Garcia-Pedrajas MD, Luque-Romero FL, et al. 1991. An association between mutagenicity in rodents for 16 halogenated aliphatic hydrocarbons. Mutagenesis 6 199-205. 

Bignami, M., Conti, G, Conti, L., Crebelli, R., Misuraca, F., Puglia, A.M., Randazzo, R., Sciandrello, G. Carere, A. (1980) Mutagenicity of halogenated aliphatic hydrocarbons in Salmonella typhimurium, Streptomyces coelicolor and Aspergillus nidulans. Chem.-biol. Interact., 30, 9-23... 

Properties Colorless clear vise, liq. mild odor sol. in most org. soivs., 95% ethanol, acetone, DMSO, ketones, chlorinated hydrocarbons sol. < 1 mg/ml in water insol. in aliphatic hydrocarbons m.w. 430.91 dens. 1.508 g/cm (22.2 C) vapor pressure 10.3 mm Hg (25 C) f.p. 27 C b.p. 236-237 C (5 mm) flash pt. 252 C ref. index 1.5022 Toxicology LD50 (oral, rat) 1850 mg/kg, (skin, rabbit) > 23,700 mg/kg mod. toxic by ing. may cause irritation of skin, respiratory tract cholinesterase inhibitor may cause tremors, convulsions, irritability, hypermotility, diarrhea, enzyme inhibition, change in blood/tissue levels, changes in liver/kidney wt questionable carcinogen experimental teratogen and reproductive effects mutagenic data ... 

The products from the oxidation of alkylbenzenes under simulated atmospheric conditions have been noted earlier. Both ring epoxides that were highly functionalized and aliphatic epoxides from ring fission were tentatively identified (Yu and Jeffries 1997), and formation of the latter, many of which are mutagenic, may cause further concern over transformation products from monocyclic aromatic hydrocarbons in the atmosphere. 

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