Aldosterone biological actions

The first demonstration of intracellular steroid-hormone receptors was by Jensen and Jacobson (1962) for estradiol. Levinson et al. (1972) showed that hormone binding to the glucocorticoid receptor in cultured rat hepatoma cells takes place inside the cell membrane rather than at the cell surface, but did not exclude the existence of other biological actions of steroids mediated by surface membrane receptors. Indeed, Ozegovic et al. (1977) have shown that aldosterone binds to isolated kidney plasma membranes and have proposed that this steroid-membrane interaction may reflect an early event in the transmembrance movement of aldosterone. 

---