Aldol reaction generalized

Allyltributyltin, 10 Boron trifluoride etherate, 43 Di-jjL-carbonylhexacarbonyldicobalt, 99 Grignard reagents, 138 Ketenylidenetriphenvlphosphorane, 154 Methoxyamine, 177 Reformatsky reagent, 346 Tin(IV) chloride, 300 Tributylcrotyltin, 10 Aldol reactions General considerations, 202 Directed aldols using imines Norephedrine, 200... 

The Aldol Reaction General Acid and Base Catalysis... 

The metal carbene anions represent C-nucleophiles which can be applied to aldol-type reactions. The first aldol reactions were performed with stoichiometric amounts of carbene complex anions [6a] later it turned out that higher yields are obtained when the reaction is run under equilibrating conditions (Scheme 4). [9] Clean aldol reactions generally require non-enolizable aldehydes. Nevertheless, an aldol condensation involving an enolizable aldehyde has been reported using catalytic amounts of base. [10]... 

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