Alder, Lutz

Pindur U., Lutz G., Otto C. Acceleration and Selectivity Enhancement of Diels-Alder Reactions by Special and Catalytic Methods Chem. Rev. 1993 93 741 761... 

Methods submitted by industry are partly used for implementation in national collections of analytical methods (e.g., in the German Method Collection of 35 LMBG). This activity often involves a modification of the analytical procedure and extended validation. Some examples for this approach are discussed by Lutz Alder in this Handbook. 

The authors express their gratitude to Ralf Eischer, Lutz Alder and Karsten Hohgardt for their valuable contributions and fmitful discussions and to Inger Biirig for reading the manuscript. 

Lutz Alder Federal Institute for Health Protection of Consumers and Veterinary Medicine (BgVV), Berlin, Germany... 

Pindur, U., Lutz, G., Otto, C. Acceleration and selectivity enhancement of Diels-Alder reactions by special and catalytic methods. Chem. Rev. 1993, 93, 741-761. 

Cu A AC) (Johnson et at, 2008), historically the first one that has been given this name, is up to now the most apphed method. However, despite the popularity of this reaction on a lab scale, its widespread use is limited by the presence of a cytotoxic transition metal and the need for potentially explosive azides. For that reason, a range of copper-ftee click approaches are now intensively studied, including thiol-ene/yne addition reactions and (ultrafast) hetero-Diels— Alder cycloaddition (HDA) reactions, which are believed to have great potential to become as popular as the CuAAC in the click chemistry toolbox (Lutz, 2008 Becer et ai, 2009). 

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