Aldehydes, oxidized metabolites, role

Alcohols are oxidized to aldehydes by the liver enzyme alcohol dehydrogenase, and aldehydes to carboxylic acids by aldehyde dehydrogenase. In mammals, monooxygenases can be induced by plant secondary metabolites such as a-pinene, caffeine, or isobornyl acetate. Reduction is less common and plays a role with ketones that cannot be further oxidized. Hydrolysis, the degradation of a compound with addition of water, is also less common than oxidation. 

Reactive aldehydes generated from hpid peroxidation are involved in CVD (266). Another example lies with the role of oxidative stress in the pathophysiology of asthma (267). Lipid peroxidation, as determined by plasma iso-prostanes, is related to disease severity in mild asthma. Tumor cell lines are sensitive to PUFA and to associated oxidation products (268). This sensitivity depends on the antioxidant defense mechanism, as well as on culture conditions. Hydroperoxy docosahexaenoic acid is a major metabolite, responsible for the cytotoxicity of DHA. 

IV. Polyamines as Inhibitors of the Induction of iNOS Role of Oxidized Aldehyde Metabolites ... 

---