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Aldehydes in the Mannich reaction

The authors have demonstrated for the first time the use of a,a-disubstituted aldehydes in the Mannich reaction to generate all-carbon quaternary stereocenters. The enantioselective p-formyl a-aminoacid derivatives 170 were further transformed to spiro- p-lactams 171 using oxidation followed by basic hydrolysis and acidification. [Pg.80]

In Summary Condensation of aldehydes (e.g., formaldehyde) with amines furnishes imin-ium ions, which are electrophihc and may be attacked by the enols of ketones (or other aldehydes) in the Mannich reaction. The products are j8-aminocarbonyl compounds. [Pg.958]


See also in sourсe #XX -- [ Pg.1189 ]

See also in sourсe #XX -- [ Pg.161 ]

See also in sourсe #XX -- [ Pg.161 ]




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