Alcohols intermolecular inversion

This means that the phase changes observed have comparatively less Importance for the thermodynamics of the system. On the other hand, the changes and modifications of the association structures within the isotropic liquid hydrocarbon or alcohol phase pose a series of interesting problems. Some of these have recently been treated in review articles by Fendler — who focussed on surfactant inter-association emphasizing consecutive equilibria and their thermodynamics. The following description will focus on the Intermolecular interaction between different kinds of molecules and the Importance of these interactions for the "inverse" association structures. 

The inversion of secondary alcohols into the corresponding esters, followed by hydrolysis of the ester intermediate into the inverted alcohol, has been one of the most commonly used applications of the Mitsunobu reaction during the last forty years. After the initial discovery by Mitsunobu, this method has been used hundreds of times to invert alcohols in all kinds of organic molecules. Intermolecular and intramolecular inversion reactions are possible, although the latter reaction to make lactones is used much less... 

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