Alcohol from carbonyls

Alcohols from Carbonyl Compounds. Oxidation-Reduction and Organometallic Compounds... 

The formation of chiral alcohols from carbonyl compounds has been fairly widely studied by reactions of aldehydes or ketones with organometallic reagents in the presence of chiral ligands. Mukaiyama et al. 1081 obtained excellent results (up to 94% e.e.) in at least stoichiometric addition of the chiral auxiliary to the carbonyl substrate and the organometallic reagent. 

H. Hofer and M. Moist, Justus Liebigs Am. Chem. 323 285 (1902). Alcohols from carbonylic acid. 

Chiral Ligand of L1A1H4 for the Enantioselective Reduction of Alkyl Phenyl Ketones. Optically active alcohols are important synthetic intermediates. There are two major chemical methods for synthesizing optically active alcohols from carbonyl compounds. One is asymmetric (enantioselective) reduction of ketones. The other is asymmetric (enantioselective) alkylation of aldehydes. Extensive attempts have been reported to modify Lithium Aluminum Hydride with chiral ligands in order to achieve enantioselective reduction of ketones. However, most of the chiral ligands used for the modification of LiAlHq are unidentate or bidentate, such as alcohol, phenol, amino alcohol, or amine derivatives. 

Reductions catalyzed by alcohol dehydrogenases formation of chiral enantio-merically pure alcohols from carbonyl compounds. 

Additions with Friedel-Crafts reaction Alcohols from carbonyl compounds... 

Alcohols from Carbonyl Compounds OxIdatlon-Reductlon and Organometalllc Compounds 542... 

CHAPTER 12 ALCOHOLS FROM CARBONYL OOMPOUNDS Oxidation-Reduction and Organometaiiic Compounds... 

CHAPTER 12 ALCOHOLS FROM CARBONYL COMPOUNDS Oxidation-Reduction and Organometaiiic Compounds 12.20 Predict the major organic product from each of the following reactions. 

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