Albumin conjugates internalization

Figure 1 Schematic diagram of the arrangement of a tissue-based membrane biosensor (A) slice of tissue (B) bovine serum albumin conjugate layer (C) carbon dioxide gas permeable membrane (D) 0-ring (E) internal electrolyte solution (F) pH-sensing glass membrane (G) plastic electrode body. (Reproduced with permission from Kurlyama S and Rechnitz GA (1981) Analytica Chimica Acta 131 91.)...

It is absorbed almost completely from the Gl-tract after an oral administration. Peak plasma levels (- 55 mg.mL are accomplished after 4 to 5 doses at an internal of 12 hours. It has been observed that more than 99% gets bound to serum albumin. The mean plasma half-life is nearly 13 hour. About 95% of a dose gets excreted in the urine, largely as conjugates of naproxen and its corresponding inactive metabolite 6-demethyl-naproxen. 

Ulbrich, K., et al. Interaction of folate-conjugated human serum albumin (HSA) nanoparticles with tumour cells. International Journal of Pharmaceutics, 2011,406 128-134. Zhang, L., et al.. Uptake of folate-conjugated albumin nanoparticles to the SKOV3 cells. International Journal of Pharmaceutics, 287 155-162, 2004. 

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