Albino locus

Kwon, B. S., Haq, A. K Pomerantz, S. H., and Halaban, R. (1987b). Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus. Proc. Natl. Acad. Sci. USA 84 7473-7477. 

Furthermore, a melanocyte line that has reverted in culture from albino to wild type has restored the cysteine codon at position 85 (Jackson and Bennett, 1990). In vivo studies (see below) proved that the c-locus encodes tyrosinase and showed that expression of a tyrosinase minigene rescues the albino phenotype (Yokoyama et al., 1990 Tanaka et al., 1990 Beermann et al., 1990). 

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